Principles of Biochemistry (4th Edition)

Principles of Biochemistry (4th Edition) PDF

Author: Robert A Horton and Laurence A. Moran

Publisher: Pearson Education Limited


Publish Date: July 9, 2005

ISBN-10: 0131453068

Pages: 896

File Type: PDF

Language: English

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Book Preface

To the Student

Welcome to biochemistry—the study of the of life at the molecular level. As you venture into this exciting and dynamic discipline, you’ll discover many new and wonderful things. You’ll learn how some enzymes can catalyze chemical reactions at speeds close to theoretical limits—reactions that would otherwise occur only at imperceptibly low rates. You’ll learn about the forces that maintain biomolecular structure and how even some of the weakest of those forces make life possible. You’ll also learn how biochemistry has thousands of applications in day-to-day life—in medicine, drug design, nutrition, forensic science, agriculture, and manufacturing. In short, you’ll begin a journey of discovery about how biochemistry makes life both possible and better. Before we begin, we would like to offer a few words of advice:

Don’t just memorize facts; instead, understand principles

In this book, we have tried to identify the most important principles of biochemistry. Every year, a million or so research papers are published. Half of them describe the results of research in some area of biochemistry. Because the knowledge base of biochemistry is continuously expanding, we must grasp the underlying themes of this science in order to understand it. This textbook is designed to expand on the foundation you have acquired in your chemistry and biology courses and to provide you with a biochemical framework that will allow you to understand new phenomena as you meet them. As you progress in your studies, you will encounter many examples that flesh out the framework we describe in this book. These individual facts are useful in illuminating the basic principles.

Be prepared to learn a new vocabulary

An understanding of biochemical facts requires that you learn a biochemical vocabulary. This vocabulary includes the chemical structures of a number of key molecules. These molecules are grouped into families based on their structures and functions. You will also learn how to distinguish among members of each family and how small molecules combine to form macromolecules such as proteins and nucleic acids. As with any newly studied discipline, the more familiar you are with the vocabulary the more easily you can learn and appreciate the scientific literature.

Test your understanding

True mastery of biochemistry lies with learning how to apply your knowledge and how to solve problems. Each chapter concludes with a set of carefully crafted problems that test your understanding of core principles. Many of these problems are mini case studies that present the problem within the context of a real biochemical puzzle.

Brief Contents

PART ONE Introduction
1 Introduction to Biochemistry
2 Water
PART TWO Structure and Function
3 Amino Acids and the Primary Structures of Proteins
4 Proteins: Three-Dimensional Structure and Function
5 Properties of Enzymes
6 Mechanisms of Enzymes
7 Coenzymes and Vitamins
8 Carbohydrates
9 Lipids and Membranes
PART THREE Metabolism and Bioenergetics
10 Introduction to Metabolism
11 Glycolysis
12 Gluconeogenesis, The Pentose Phosphate Pathway, and Glycogen Metabolism
13 The Citric Acid Cycle
14 Electron Transport and ATP Synthesis
15 Photosynthesis
16 Lipid Metabolism
17 Amino Acid Metabolism
18 Nucleotide Metabolism
PART FOUR Biological Information Flow
19 Nucleic Acids
20 DNA Replication, Repair, and Recombination
21 Transcription and RNA Processing
22 Protein Synthesis
23 Recombinant DNA Technology

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