Molecular Cell Biology – 7th edition

Molecular Cell Biology – 7th edition PDF

Author: Harvey Lodish and Arnold Berk

Publisher: W. H. Freeman


Publish Date: May 2, 2012

ISBN-10: 142923413X

Pages: 973

File Type: PDF

Language: English

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Book Preface

In writing the seventh edition of Molecular Cell Biology we have incorporated many of the spectacular advances made over the past four years in biomedical science, driven in part by new experimental technologies that have revolutionized many fields . Fast techniques for sequencing DNA and RNA, for example, have uncovered many novel noncoding RNAs that regulate gene expression and identi­fied hundreds of human genes that affect diseases such as diabetes, osteoporosis, and cancer. Genomics has also led to many novel insights into the evolution of life forms and the functions of individual members of multiprotein families. Exploring the most current developments in the field is al­ways a priority in writing a new edition, but it is also impor­tant to us to communicate the basics of cell biology clearly. To this end, in addition to introducing new discoveries and technologies, we have streamlined and reorganized several chapters to clarify processes and concepts for students.

New Co-Author, Angelika Amon

The new edition of MCB introduces a new member to our author team, respected researcher and teacher Angelika Amon of the Massachusem Institute of Technology. Her laboratory uses the budding yeast S. cerevisiae and mouse and cell culture models to gain a detailed molecular under­standing of the regulatory circuits that control chromosome segregation and the effects of aneuploidy on cell physiology. Dr. Amon also teaches undergraduate and graduate courses in Cell Biology and Genetics.  Revised, Cutting Edge Content

The seventh edition of Mr;,lecular Cell Biology includes new and improved chapters:

•    “Molecules, Cells and Evolution” (Chapter 1) now frames cell biology in the light of evolution: this perspective explains why scientists pick particular unicellular and multicellular “model” organisms to study specific genes and proteins that are important for cellular function.
•    ”Culturing, Visualizing, and Perturbing Cells” (Chapter 9) has been rewritten to include cutting edge methods includ­ing FRAP, FRET, siRNA, and chemical biology, making it a state-of-the-art methods chapter.
•    “Signal Transduction and G Protein-Coupled Receptors” and “Signaling Pathways that Control Gene Expression” (Chapters 15 and 16) have been reorganized and illustrated with simplified overview figures, to help students navigate the complexity of signaling pathways.

•    “The Eukaryotic Cell Cycle” (Chapter 19) now begins with the concepts of “START” (a cell’s commitment to entering the cell cycle starting with DNA synthesis) and then progresses through the cycle stages. The chapter focuses on yeast and mammals and uses general names for cell cycle components when possible to improve student understanding.
•    “Stem Cells, Cell Asymmetry, and Cell Death” (Chapter 21) now incorporates developmental topics, including new cover­age of induced pluripotcnt stem (iPS) cells.

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