Harrison’s Endocrinology, 4E
Harrison’s Principles o Internal Medicine has been a respected source o medical in ormation or students, residents, internists, amily physicians, and other health care providers or many decades. T is book, Harrison’s Endocrinology, now in its ourth edition, is a compilation o chapters related to the specialty o endocrinology, a eld that includes some o the most commonly encountered diseases such as diabetes mellitus, obesity, thyroid disorders, and metabolic bone disease. Our readers consistently note the practical value o the specialty sections o Harrison’s. Speci cally, these sections include a rigorous explanation o pathophysiology as a background or di erential diagnosis and patient management. Our goal was to bring this in ormation to readers in a more compact and usable orm. Because the topic is more ocused, it is possible to improve the presentation o the material by enlarging the text and the tables and providing clearly illustrated gures that elucidate challenging concepts. We have also included a Review and Sel -Assessment section that includes questions and answers to provoke re ection and to provide additional teaching points. T e clinical mani estations o endocrine disorders can usually be explained by considering the physiologic role o hormones, which are either de cient or excessive. T us, a thorough understanding o hormone action and principles o hormone eedback arms the clinician with a logical diagnostic approach and a conceptual ramework or treating patients. T e rst chapter o the book, Approach to the Patient with Endocrine Disorders, provides this type o “systems” overview. Using numerous examples o translational research, this introduction links genetics, cell biology, and physiology with pathophysiology and treatment. T e integration o pathophysiology with clinical management is a hallmark o Harrison’s, and can be ound throughout each o the subsequent disease-oriented chapters. T e book is divided into six main sections that re ect the physiologic roots o endocrinology: (I) Introduction to Endocrinology; (II) Pituitary, T yroid, and Adrenal Disorders; (III)
Reproductive Endocrinology; (IV) Diabetes Mellitus, Obesity, Lipoprotein Metabolism; (V) Disorders A ecting Multiple Endocrine Systems; and (VI) Disorders o Bone and Calcium Metabolism. While Harrison’s Endocrinology is classic in its organization, readers will sense the impact o scienti c advances as they explore the individual chapters in each section. In addition to the dramatic discoveries emanating rom genetics and molecular biology, the introduction o an unprecedented number o new drugs, particularly or the management o diabetes, hypogonadism, and osteoporosis, is trans orming the eld o endocrinology. Numerous recent clinical studies involving common diseases like diabetes, obesity, hypothyroidism, hypogonadism, and osteoporosis provide power ul evidence or medical decision making and treatment. T ese rapid changes in endocrinology are exciting or new students o medicine and underscore the need or practicing physicians to continuously update their knowledge base and clinical skills. Our access to in ormation through web-based journals and databases is remarkably e cient, but also daunting, creating a need or books that synthesize concepts and highlight important acts. T e preparation o these chapters is there ore a special craf that requires distillation o core in ormation rom the ever-expanding knowledge base. T e editors are indebted to our authors, a group o internationally recognized authorities who are masters at providing a comprehensive overview while being able to distill a topic into a concise and interesting chapter. We are also indebted to our colleagues at McGraw-Hill. Jim Shanahan is a tireless champion or Harrison’s, and these books were impeccably produced by Kim Davis. We hope you nd this book use ul in your e ort to achieve continuous learning on behal o your patients.
J. Larry Jameson, MD, PhD
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