Cellular and Molecular Immunology, 9e
This ninth edition of Cellular and Molecular Immunology includes substantial revisions, which we made to keep the textbook current with scientific advances and, at the same time, maintain the clear and readable style that has been typical of previous editions. Whenever we have added new information, we have focused primarily on important concepts and have not increased the length of the book. We have also rewritten many sections for increased clarity, accuracy, and completeness.
A general theme in modern immunology is that the field is moving beyond establishing fundamental principles of the mechanisms of immune responses to applying these principles to understand human disease and develop new therapies. The revolution in immunological therapies over the last twenty years has been extraordinary. It is especially satisfying for immunologists that some of the most innovative and effective immunotherapies have been developed because the basic science has matured and the complex mechanisms of immune activation and regulation have been elucidated in increasing detail. In this edition of the book, we have paid special attention to the clinical relevance of immunology and have emphasized how newly developed therapies work and what their
strengths and pitfalls are.
In addition to these translational aspects of immunology, we have also updated basic concepts wherever there has been significant new understanding. Some examples of these fundamental advances include current views on innate lymphoid cells, the biology of inflammasome activation, the role of follicular helper T cells in antibody responses in germinal centers, newly described memory lymphocyte subsets, and the protective and pathogenic roles of effector T cells.
As in previous editions, each chapter is written so that it can be read and understood on its own, without referring to other chapters. In order to do this, it is often necessary to repeat some basic concepts and general principles that are covered in other chapters. We feel such repetition is valuable because it enables the reader to consolidate learning and to understand the content of each chapter independently of the others. We also feel this is helpful for faculty teaching from the book, because they can consider each chapter the topic of one or two lectures.
We have also continued to improve our illustration program. All illustrations have been revised to provide more visual depth and clarity. New figures have been added, and previously used figures have been reviewed and often changed for accuracy. We have kept design features such as the use of bold italic text to highlight “take-home messages” to make the book easy to read. The lists of suggested readings continue to emphasize recent review articles that provide in-depth coverage of particular topics for the interested reader. We have divided the lists into sections based on themes to help readers find the most useful articles for their needs. This edition also includes a page listing the online resources available to instructors and students (page vii).
Individuals who have helped us with specific topics are (in alphabetical order) Drs. Mark Anderson, Jason Cyster, Andrew Gross, Richard Locksley, Miriam Merad, Michael Rosenblum, Wayne Shreffler, and Catherine Wu; all were generous with advice and comments. Our illustrators, David and Alexandra Baker of DNA Illustrations, remain full partners in the book and provide invaluable suggestions for clarity and accuracy. Several members of the Elsevier staff played critical roles. Our editor, James Merritt, has been a source of support and encouragement. Our managing editor, Rebecca Gruliow, shepherded the book through its preparation and into production. Ryan Cook was responsible for managing the design, and John Casey was invaluable throughout the production stage. We also owe a debt of gratitude to our families for their unflagging support and their tolerance of our absences.
Finally, our students were the original inspiration for the first edition of this book, and we remain continually grateful to them, because from them we learn how to think about the science of immunology and how to communicate knowledge in the clearest and most meaningful way.
ABUL K. ABBAS
ANDREW H. LICHTMAN
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