An Introduction to Human Disease: Pathology and Pathophysiology Correlations 9th Edition
There have been many new developments and advances in medicine since the last edition of this book. This edition has many rewritten sections to incorporate new concepts and treatment methods. I have rearranged the location of the material in some chapters, added material on some new diseases that have become more important in medical practice, added some new tables to existing chapters, and updated the annotated list of references. I have expanded the annotations, which can be used to supplement the text material. I have concentrated primarily on references in the New England Journal of Medicine and the Journal of the American Medical Association because they are the most likely journals to be available in the libraries used by students. The same basic organization of the book has been retained as described in the “About the Book” section, because the format seems to be popular with students. The student workbook has been rearranged in some areas to conform to the textbook chapters, and also was upgraded by adding questions dealing with the new material.
New material has been added to almost every chapter, and many new references have been added.
• Chapter 1 contains additional material on the applications and limitations of PET scans.
• Chapter 2 describes the role of microRNA and how it regulates gene functions.
• Chapter 5 contains new material on lupus erythematosus and scleroderma and also includes two new photographs.
• Chapter 6 has expanded material on herpes zoster (shingles) and the vaccine to prevent it.
• Chapter 7 deals with Pneumocystis jiroveci, which now is classified as a fungus.
• Chapter 8 contains updated material on HIV, including recommendations for early treatment to prevent damage to the immune system and to help prevent the spread of HIV to contacts.
• Chapter 9 explains that prenatal tests for Down syndrome now are offered to all women, not just older women. The tests are described, along with their applications and limitations.
• Chapter 10 describes new, less-aggressive treatment of Hodgkin disease and other neoplastic diseases affecting the bone marrow to reduce the risk of later therapy-related complications.
• Chapters 11 and 12 explain how new anticoagulant drugs offer treatment advantages over Warfarin. The d-dimer test helps diagnose a pulmonary embolism.
• Chapter 13 contains an expanded section on artificial heart valves, with several new photographs, and describes new methods of valve replacement. Treatment of acute coronary syndromes is updated, along with case studies.
• Chapter 14 provides a new section on oxygen transport by hemoglobin, along with an expanded section on problems related to sickle cell trait. Immunosuppression of the bone marrow before marrow transplant is less aggressive and yields better results.
• Chapter 15 contains an augmented chest CT screening test for lung carcinoma that permits earlier detection and improves survival but is more expensive and also yields false-positive results.
• Chapter 16 contains updated material on the harmful effects of estrogen-progestin on breast cancer risk, and risk-reduction surgery for BRCA-positive women is discussed.
• Chapter 17 discusses the role of PAP smears and tests for HPV infection. A new postcoital contraceptive is available.
• Chapter 18 provides additional material on twin-to-twin transfusion.
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